| Skater | Pos | Team | GP | G | A | P | +/- | PiM | GW | GT | ATOI | PPG | PPP | SHG | S | S% | BkS | Hits | P/GP | FO% | HT |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sidney Crosby | C | BUF | 73 | 43 | 69 | 112 | +23 | 148 | 11 | 1 | 22:34 | 14 | 36 | 0 | 317 | 13.6 | 36 | 152 | 1.53 | 52.0 | 0 |
| Thomas Vanek | LW | BUF | 77 | 32 | 43 | 75 | +12 | 85 | 4 | 1 | 21:05 | 9 | 23 | 1 | 266 | 12.0 | 25 | 86 | 0.97 | 43.8 | 0 |
| Derek Roy | C | BUF | 78 | 28 | 40 | 68 | +13 | 49 | 5 | 1 | 19:30 | 8 | 25 | 2 | 240 | 11.7 | 32 | 123 | 0.87 | 51.5 | 0 |
| Jason Pominville | RW | BUF | 79 | 30 | 31 | 61 | +24 | 14 | 5 | 4 | 20:15 | 10 | 17 | 2 | 172 | 17.4 | 25 | 92 | 0.77 | 48.6 | 0 |
| Chris Kunitz | LW | BUF | 74 | 21 | 19 | 40 | +8 | 59 | 1 | 1 | 15:38 | 10 | 16 | 0 | 187 | 11.2 | 29 | 163 | 0.54 | 46.6 | 0 |
| Nicklas Lidstrom | D | SJS / BUF | 72 | 5 | 33 | 38 | -5 | 22 | 2 | 0 | 27:21 | 5 | 17 | 0 | 155 | 3.2 | 101 | 76 | 0.53 | - | 0 |
| Ryan Malone | LW | ANH / BUF | 80 | 13 | 22 | 35 | -18 | 149 | 1 | 1 | 16:46 | 4 | 10 | 0 | 152 | 8.6 | 20 | 150 | 0.44 | 39.6 | 0 |
| Toni Lydman | D | BUF / SJS / BOS | 86 | 5 | 28 | 33 | +6 | 113 | 1 | 0 | 26:18 | 2 | 12 | 0 | 95 | 5.3 | 114 | 199 | 0.38 | - | 0 |
| Colby Armstrong | LW | BUF / WSH | 78 | 15 | 12 | 27 | +12 | 66 | 1 | 2 | 13:56 | 4 | 7 | 1 | 127 | 11.8 | 19 | 115 | 0.35 | 33.7 | 0 |
| Darroll Powe | C | BUF | 82 | 11 | 14 | 25 | +1 | 33 | 2 | 0 | 11:21 | 0 | 2 | 0 | 87 | 12.6 | 14 | 111 | 0.30 | 46.7 | 0 |
| Tyler Myers | D | BUF | 76 | 6 | 13 | 19 | +4 | 51 | 0 | 0 | 21:34 | 1 | 6 | 0 | 112 | 5.4 | 81 | 111 | 0.25 | - | 0 |
| Kyle Cumiskey | D | ANH / SJS / BUF | 80 | 3 | 16 | 19 | +4 | 29 | 0 | 0 | 15:42 | 0 | 1 | 0 | 72 | 4.2 | 50 | 39 | 0.24 | - | 0 |
| Anton Volchenkov | D | BUF | 78 | 1 | 18 | 19 | +28 | 162 | 0 | 0 | 25:07 | 0 | 4 | 0 | 69 | 1.4 | 111 | 159 | 0.24 | - | 0 |
| Mike Grier | RW | BUF | 82 | 9 | 9 | 18 | -4 | 5 | 2 | 0 | 13:25 | 0 | 0 | 0 | 105 | 8.6 | 30 | 83 | 0.22 | 50.0 | 0 |
| Mark Giordano | D | BUF | 72 | 2 | 16 | 18 | -4 | 102 | 0 | 0 | 21:51 | 2 | 6 | 0 | 62 | 3.2 | 87 | 120 | 0.25 | - | 0 |
| Paul Gaustad | C | BUF | 44 | 5 | 10 | 15 | -8 | 36 | 3 | 0 | 15:20 | 0 | 1 | 0 | 80 | 6.2 | 11 | 96 | 0.34 | 53.1 | 0 |
| Jeff Halpern | C | WSH / BUF | 78 | 6 | 7 | 13 | -10 | 14 | 1 | 1 | 9:59 | 0 | 0 | 1 | 77 | 7.8 | 10 | 44 | 0.17 | 59.1 | 0 |
| Mike Weaver | D | SJS / BUF | 81 | 4 | 9 | 13 | +8 | 26 | 0 | 0 | 16:23 | 0 | 0 | 0 | 66 | 6.1 | 69 | 87 | 0.16 | - | 0 |
| Henrik Tallinder | D | BUF / CLB | 80 | 2 | 9 | 11 | -2 | 37 | 0 | 0 | 15:57 | 1 | 3 | 0 | 56 | 3.6 | 63 | 71 | 0.14 | - | 0 |
| Patrick Kaleta | RW | BUF | 80 | 6 | 4 | 10 | +1 | 78 | 1 | 1 | 8:25 | 1 | 1 | 0 | 77 | 7.8 | 8 | 97 | 0.13 | 48.1 | 0 |
| Chris Thorburn | C | BUF | 82 | 4 | 4 | 8 | -10 | 42 | 1 | 0 | 9:10 | 1 | 3 | 0 | 57 | 7.0 | 16 | 74 | 0.10 | 50.7 | 0 |
| Nathan Gerbe (R) | C | BUF | 18 | 3 | 2 | 5 | +3 | 21 | 0 | 0 | 8:27 | 1 | 2 | 0 | 32 | 9.4 | 3 | 13 | 0.28 | 30.0 | 0 |
| Cody McLeod | LW | BUF / ANH / BOS | 64 | 0 | 4 | 4 | -5 | 49 | 0 | 0 | 8:04 | 0 | 0 | 0 | 47 | 0.0 | 8 | 72 | 0.06 | 75.0 | 0 |
| Mike Weber (R) | D | BUF | 27 | 0 | 3 | 3 | -4 | 23 | 0 | 0 | 12:22 | 0 | 0 | 0 | 13 | 0.0 | 9 | 26 | 0.11 | - | 0 |
| Dustin Jeffrey (R) | C | BUF | 17 | 1 | 1 | 2 | -1 | 0 | 1 | 0 | 8:44 | 0 | 0 | 0 | 16 | 6.2 | 2 | 7 | 0.12 | 50.7 | 0 |
| Jeremy Morin (R) | LW | BUF | 2 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 15:42 | 0 | 1 | 0 | 2 | 0.0 | 1 | 5 | 1.00 | 100.0 | 0 |
| Chris Butler | D | BUF / ANH | 54 | 0 | 2 | 2 | +11 | 32 | 0 | 0 | 11:33 | 0 | 0 | 0 | 22 | 0.0 | 34 | 24 | 0.04 | - | 0 |
| Lennart Petrell | C | BUF / WPG | 28 | 0 | 1 | 1 | +1 | 8 | 0 | 0 | 7:19 | 0 | 0 | 0 | 7 | 0.0 | 4 | 17 | 0.04 | 30.8 | 0 |
| Brian Strait (R) | D | BUF | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 11:33 | 0 | 0 | 0 | 0 | - | 0 | 2 | 0.00 | - | 0 |
| Teemu Hartikainen (R) | LW | BUF | 2 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 4:35 | 0 | 0 | 0 | 1 | 0.0 | 0 | 0 | 0.00 | - | 0 |
| Luca Sbisa (R) | D | BUF | 30 | 0 | 0 | 0 | -4 | 0 | 0 | 0 | 11:13 | 0 | 0 | 0 | 2 | 0.0 | 12 | 35 | 0.00 | - | 0 |
| 31 Skaters | 1856 | 255 | 441 | 696 | - | 1455 | 42 | 13 | - | 73 | 193 | 7 | 2773 | - | 1024 | 2449 | 10.57 | - | 0 |