| Skater | Pos | Team | GP | G | A | P | +/- | PiM | GW | GT | ATOI | PPG | PPP | SHG | S | S% | BkS | Hits | P/GP | FO% | HT |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sidney Crosby | C | BUF | 73 | 30 | 44 | 74 | +11 | 11 | 4 | 1 | 23:28 | 6 | 19 | 0 | 273 | 11.0 | 7 | 51 | 1.01 | 51.0 | 0 |
| Thomas Vanek | LW | BUF | 82 | 26 | 43 | 69 | +15 | 34 | 4 | 1 | 20:51 | 9 | 22 | 1 | 232 | 11.2 | 9 | 120 | 0.84 | 31.8 | 0 |
| Ryan Malone | LW | BUF | 82 | 18 | 43 | 61 | +10 | 52 | 3 | 0 | 16:07 | 4 | 18 | 0 | 195 | 9.2 | 7 | 157 | 0.74 | 37.9 | 0 |
| Derek Roy | C | BUF | 81 | 21 | 38 | 59 | +9 | 28 | 4 | 3 | 18:43 | 4 | 18 | 0 | 202 | 10.4 | 16 | 26 | 0.73 | 50.1 | 0 |
| Chris Kunitz | LW | BUF | 82 | 26 | 32 | 58 | +12 | 38 | 6 | 3 | 19:03 | 8 | 17 | 1 | 230 | 11.3 | 6 | 118 | 0.71 | 36.0 | 1 |
| Paul Gaustad | C | BUF | 82 | 14 | 23 | 37 | +5 | 45 | 2 | 0 | 13:07 | 0 | 3 | 0 | 122 | 11.5 | 12 | 83 | 0.45 | 57.5 | 0 |
| Tyler Myers | D | BUF | 82 | 15 | 19 | 34 | +6 | 67 | 1 | 1 | 22:09 | 7 | 13 | 0 | 86 | 17.4 | 105 | 67 | 0.41 | - | 0 |
| Mike Weaver | D | BUF | 82 | 7 | 27 | 34 | +11 | 60 | 0 | 0 | 24:20 | 4 | 11 | 0 | 110 | 6.4 | 132 | 61 | 0.41 | - | 0 |
| Joni Pitkanen | D | BUF | 66 | 8 | 25 | 33 | +9 | 31 | 4 | 1 | 19:47 | 6 | 11 | 0 | 87 | 9.2 | 52 | 44 | 0.50 | - | 0 |
| Cal Clutterbuck | LW | BUF | 82 | 11 | 20 | 31 | +3 | 118 | 3 | 0 | 19:36 | 3 | 9 | 0 | 152 | 7.2 | 17 | 275 | 0.38 | 31.7 | 0 |
| Ruslan Fedotenko | C | BUF | 82 | 10 | 18 | 28 | -3 | 8 | 0 | 2 | 11:50 | 0 | 1 | 0 | 140 | 7.1 | 5 | 16 | 0.34 | 32.7 | 0 |
| Anton Volchenkov | D | BUF | 67 | 5 | 19 | 24 | +9 | 164 | 1 | 0 | 20:03 | 1 | 2 | 0 | 52 | 9.6 | 96 | 180 | 0.36 | - | 0 |
| Darroll Powe | C | BUF | 82 | 9 | 7 | 16 | -6 | 108 | 1 | 2 | 12:59 | 0 | 0 | 0 | 91 | 9.9 | 12 | 131 | 0.20 | 44.4 | 0 |
| Luca Sbisa | D | BUF | 81 | 3 | 10 | 13 | -7 | 97 | 0 | 0 | 16:11 | 1 | 3 | 0 | 41 | 7.3 | 68 | 159 | 0.16 | - | 0 |
| Luke Adam (R) | C | BUF | 63 | 3 | 6 | 9 | -8 | 12 | 1 | 1 | 11:57 | 0 | 1 | 0 | 54 | 5.6 | 3 | 36 | 0.14 | 48.3 | 0 |
| Mike Weber | D | BUF | 69 | 3 | 6 | 9 | +5 | 101 | 1 | 1 | 13:09 | 1 | 1 | 0 | 20 | 15.0 | 41 | 168 | 0.13 | - | 0 |
| Chris Thorburn | C | BUF | 82 | 3 | 4 | 7 | -8 | 24 | 0 | 0 | 6:48 | 0 | 0 | 0 | 51 | 5.9 | 2 | 59 | 0.09 | 55.5 | 0 |
| Randy Jones | D | BUF | 37 | 1 | 4 | 5 | -7 | 28 | 0 | 0 | 15:46 | 0 | 1 | 0 | 13 | 7.7 | 37 | 23 | 0.14 | - | 0 |
| Andrew Desjardins (R) | C | BUF | 56 | 0 | 4 | 4 | -11 | 6 | 0 | 0 | 6:05 | 0 | 0 | 0 | 23 | 0.0 | 4 | 13 | 0.07 | 50.7 | 0 |
| Patrick Kaleta | RW | BUF | 28 | 1 | 0 | 1 | -8 | 17 | 0 | 0 | 7:40 | 0 | 0 | 0 | 17 | 5.9 | 4 | 41 | 0.04 | 44.4 | 0 |
| Brayden McNabb (R) | D | BUF | 2 | 0 | 0 | 0 | +1 | 0 | 0 | 0 | 13:30 | 0 | 0 | 0 | 0 | - | 0 | 0 | 0.00 | - | 0 |
| John Scott | LW | BUF | 10 | 0 | 0 | 0 | -4 | 14 | 0 | 0 | 13:43 | 0 | 0 | 0 | 3 | 0.0 | 5 | 25 | 0.00 | - | 0 |
| 22 Skaters | 1453 | 214 | 392 | 606 | - | 1063 | 35 | 16 | - | 54 | 150 | 2 | 2194 | - | 640 | 1853 | 7.85 | - | 1 |