| Skater | Pos | Team | GP | G | A | P | +/- | PiM | GW | GT | ATOI | PPG | PPP | SHG | S | S% | BkS | Hits | P/GP | FO% | HT |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sidney Crosby | C | BUF | 82 | 38 | 58 | 96 | -2 | 6 | 8 | 2 | 22:12 | 18 | 31 | 1 | 321 | 11.8 | 10 | 44 | 1.17 | 54.9 | 3 |
| Thomas Vanek | LW | BUF | 78 | 34 | 43 | 77 | +13 | 16 | 7 | 2 | 20:03 | 8 | 22 | 0 | 291 | 11.7 | 9 | 70 | 0.99 | 30.6 | 1 |
| Jarome Iginla | RW | ANH / BUF / OTT | 84 | 26 | 28 | 54 | +6 | 63 | 2 | 3 | 18:20 | 7 | 17 | 0 | 334 | 7.8 | 7 | 159 | 0.64 | 37.6 | 1 |
| James Wisniewski | D | DET / BUF | 81 | 6 | 48 | 54 | -6 | 88 | 0 | 1 | 23:38 | 5 | 19 | 0 | 116 | 5.2 | 89 | 128 | 0.67 | - | 0 |
| Troy Brouwer | LW | BUF / CHI | 81 | 21 | 29 | 50 | -5 | 58 | 5 | 2 | 17:51 | 4 | 12 | 0 | 224 | 9.4 | 10 | 221 | 0.62 | 55.8 | 0 |
| Matt Carle | D | DET / BUF | 71 | 13 | 27 | 40 | +5 | 41 | 1 | 2 | 24:50 | 4 | 7 | 0 | 101 | 12.9 | 111 | 62 | 0.56 | - | 0 |
| Matt Stajan | C | BUF / BOS / OTT / CGY | 79 | 13 | 24 | 37 | +6 | 45 | 0 | 0 | 15:16 | 1 | 3 | 0 | 141 | 9.2 | 17 | 54 | 0.47 | 52.8 | 0 |
| Dustin Brown | LW | BUF / ANH / CLB | 82 | 16 | 19 | 35 | +8 | 69 | 4 | 1 | 16:42 | 1 | 4 | 1 | 170 | 9.4 | 5 | 173 | 0.43 | 28.7 | 0 |
| Riley Sheahan (R) | C | BUF | 62 | 7 | 24 | 31 | +8 | 4 | 0 | 0 | 16:49 | 3 | 9 | 0 | 83 | 8.4 | 10 | 22 | 0.50 | 52.6 | 0 |
| Dustin Penner | RW | WSH / BUF | 77 | 15 | 15 | 30 | -18 | 22 | 3 | 1 | 16:50 | 3 | 6 | 0 | 120 | 12.5 | 12 | 92 | 0.39 | 37.8 | 0 |
| Cody Eakin | C | BUF / OTT | 73 | 14 | 16 | 30 | -11 | 32 | 0 | 1 | 14:17 | 2 | 5 | 0 | 142 | 9.9 | 8 | 63 | 0.41 | 50.2 | 1 |
| Cal Clutterbuck | LW | BUF / ANH / CGY | 79 | 15 | 14 | 29 | -4 | 46 | 3 | 1 | 13:23 | 3 | 7 | 0 | 85 | 17.6 | 7 | 148 | 0.37 | 20.5 | 0 |
| Tyler Myers | D | BUF | 74 | 4 | 23 | 27 | +6 | 53 | 1 | 0 | 21:09 | 0 | 5 | 0 | 58 | 6.9 | 64 | 125 | 0.36 | - | 0 |
| Sami Salo | D | WPG / BUF / SJS | 77 | 7 | 17 | 24 | +7 | 68 | 2 | 0 | 19:54 | 3 | 8 | 0 | 63 | 11.1 | 88 | 77 | 0.31 | - | 0 |
| Drew Miller | LW | BUF | 82 | 5 | 18 | 23 | +4 | 26 | 1 | 0 | 13:05 | 0 | 2 | 0 | 121 | 4.1 | 12 | 54 | 0.28 | 34.3 | 0 |
| Paul Byron | C | BUF | 82 | 9 | 12 | 21 | -7 | 14 | 2 | 0 | 8:32 | 1 | 3 | 0 | 77 | 11.7 | 3 | 10 | 0.26 | 37.8 | 0 |
| Derek Morris | D | PIT / BUF / ANH | 72 | 6 | 15 | 21 | -3 | 50 | 1 | 1 | 17:53 | 1 | 5 | 0 | 37 | 16.2 | 54 | 91 | 0.29 | - | 0 |
| Eric Brewer | D | BUF | 82 | 5 | 15 | 20 | +3 | 97 | 0 | 1 | 22:27 | 4 | 6 | 0 | 69 | 7.2 | 103 | 166 | 0.24 | - | 0 |
| Paul Gaustad | C | BUF | 78 | 9 | 9 | 18 | -7 | 34 | 0 | 1 | 14:29 | 0 | 3 | 1 | 109 | 8.3 | 10 | 104 | 0.23 | 60.9 | 0 |
| Patrick Dwyer | C | BUF | 79 | 9 | 9 | 18 | 0 | 63 | 4 | 0 | 13:08 | 0 | 0 | 1 | 111 | 8.1 | 18 | 53 | 0.23 | 29.9 | 0 |
| Michael Raffl | C | BUF | 39 | 7 | 11 | 18 | +2 | 21 | 2 | 0 | 15:52 | 0 | 4 | 0 | 69 | 10.1 | 5 | 50 | 0.46 | 42.4 | 0 |
| Manny Malhotra | C | BUF | 72 | 6 | 11 | 17 | +5 | 14 | 0 | 0 | 11:24 | 0 | 1 | 0 | 64 | 9.4 | 11 | 29 | 0.24 | 63.1 | 0 |
| Mike Weber | D | BUF / PHL | 66 | 3 | 14 | 17 | +7 | 100 | 1 | 0 | 17:06 | 2 | 4 | 0 | 35 | 8.6 | 51 | 177 | 0.26 | - | 0 |
| Victor Bartley | D | BUF | 48 | 4 | 10 | 14 | +6 | 18 | 1 | 0 | 15:06 | 1 | 2 | 0 | 27 | 14.8 | 32 | 37 | 0.29 | - | 0 |
| Kevan Miller | D | BUF | 72 | 6 | 7 | 13 | +8 | 64 | 1 | 0 | 17:02 | 1 | 1 | 0 | 36 | 16.7 | 81 | 48 | 0.18 | - | 0 |
| Luca Sbisa | D | BUF / DET | 25 | 2 | 10 | 12 | +6 | 23 | 1 | 1 | 18:51 | 1 | 2 | 0 | 14 | 14.3 | 19 | 29 | 0.48 | - | 0 |
| Simon Gagne | LW | PIT / BUF | 66 | 6 | 5 | 11 | -21 | 14 | 1 | 0 | 10:48 | 0 | 1 | 0 | 82 | 7.3 | 2 | 37 | 0.17 | 32.6 | 0 |
| Luke Glendening | C | BUF | 67 | 2 | 8 | 10 | -3 | 23 | 0 | 0 | 8:03 | 0 | 0 | 0 | 57 | 3.5 | 9 | 38 | 0.15 | 58.0 | 0 |
| Brett Bellemore | D | BUF | 81 | 2 | 5 | 7 | +6 | 104 | 0 | 0 | 16:26 | 0 | 0 | 0 | 42 | 4.8 | 66 | 154 | 0.09 | - | 0 |
| Jacob Josefson | C | BUF | 13 | 2 | 1 | 3 | 0 | 0 | 0 | 1 | 6:57 | 1 | 1 | 0 | 7 | 28.6 | 1 | 1 | 0.23 | 49.0 | 0 |
| Eric Gelinas (R) | D | BUF | 14 | 0 | 2 | 2 | -1 | 12 | 0 | 0 | 13:34 | 0 | 2 | 0 | 8 | 0.0 | 5 | 9 | 0.14 | - | 0 |
| Mark Pysyk (R) | D | BUF | 20 | 0 | 1 | 1 | -4 | 4 | 0 | 0 | 17:45 | 0 | 0 | 0 | 12 | 0.0 | 19 | 5 | 0.05 | - | 0 |
| 32 Skaters | 2138 | 312 | 548 | 860 | - | 1292 | 51 | 21 | - | 74 | 192 | 4 | 3226 | - | 948 | 2530 | 12.16 | - | 6 |