| Skater | Pos | Team | GP | G | A | P | +/- | PiM | GW | GT | ATOI | PPG | PPP | SHG | S | S% | BkS | Hits | P/GP | FO% | HT |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| David Pastrnak | RW | BUF | 82 | 36 | 52 | 88 | +22 | 28 | 4 | 3 | 19:36 | 11 | 25 | 0 | 360 | 10.0 | 6 | 83 | 1.07 | 36.9 | 0 |
| Sidney Crosby | C | BUF | 82 | 40 | 46 | 86 | +23 | 33 | 6 | 4 | 20:45 | 8 | 25 | 0 | 293 | 13.7 | 5 | 73 | 1.05 | 60.7 | 0 |
| Anze Kopitar | C | BUF | 82 | 24 | 42 | 66 | +4 | 12 | 5 | 2 | 19:29 | 7 | 24 | 0 | 239 | 10.0 | 13 | 18 | 0.80 | 58.7 | 0 |
| Chris Kreider | LW | BUF | 82 | 24 | 35 | 59 | +2 | 44 | 6 | 0 | 17:57 | 8 | 19 | 0 | 306 | 7.8 | 8 | 96 | 0.72 | 60.9 | 0 |
| Tage Thompson | C | BUF | 82 | 29 | 29 | 58 | -5 | 54 | 6 | 0 | 17:53 | 10 | 23 | 0 | 229 | 12.7 | 4 | 111 | 0.71 | 50.8 | 1 |
| Justin Faulk | D | BUF | 82 | 10 | 43 | 53 | +1 | 30 | 0 | 1 | 22:48 | 6 | 19 | 0 | 108 | 9.3 | 95 | 74 | 0.65 | - | 0 |
| Carter Verhaeghe | C | BUF | 82 | 21 | 30 | 51 | +13 | 34 | 3 | 0 | 18:08 | 3 | 11 | 0 | 209 | 10.0 | 7 | 119 | 0.62 | 32.6 | 0 |
| Mattias Samuelsson | D | BUF | 82 | 11 | 38 | 49 | -5 | 67 | 2 | 0 | 22:14 | 4 | 12 | 0 | 106 | 10.4 | 130 | 138 | 0.60 | - | 0 |
| Trevor Moore | LW | BUF | 82 | 22 | 22 | 44 | +1 | 30 | 3 | 1 | 17:32 | 6 | 16 | 1 | 175 | 12.6 | 8 | 78 | 0.54 | 17.2 | 0 |
| Jonas Brodin | D | MTL / CAR / BUF | 81 | 8 | 31 | 39 | -7 | 46 | 2 | 1 | 22:42 | 4 | 13 | 0 | 71 | 11.3 | 89 | 78 | 0.48 | - | 0 |
| Nick Leddy | D | BUF / COL | 84 | 5 | 28 | 33 | +13 | 26 | 1 | 0 | 19:56 | 1 | 4 | 0 | 73 | 6.8 | 124 | 51 | 0.39 | - | 0 |
| Connor Murphy | D | BUF | 82 | 4 | 29 | 33 | +14 | 131 | 0 | 0 | 18:58 | 1 | 6 | 0 | 66 | 6.1 | 110 | 200 | 0.40 | - | 0 |
| Marcus Foligno | LW | OTT / BUF | 81 | 13 | 17 | 30 | -17 | 101 | 1 | 1 | 14:58 | 3 | 8 | 0 | 157 | 8.3 | 10 | 156 | 0.37 | 33.3 | 0 |
| Zach Bogosian | D | VGK / BUF | 81 | 6 | 23 | 29 | +11 | 62 | 0 | 0 | 19:09 | 2 | 5 | 0 | 70 | 8.6 | 107 | 115 | 0.36 | - | 0 |
| Brayden McNabb | D | BUF / DET | 81 | 1 | 17 | 18 | +2 | 73 | 0 | 1 | 17:57 | 0 | 1 | 0 | 38 | 2.6 | 100 | 110 | 0.22 | - | 0 |
| Tanner Pearson | LW | BUF | 68 | 8 | 6 | 14 | -10 | 2 | 1 | 1 | 6:43 | 0 | 0 | 0 | 54 | 14.8 | 2 | 10 | 0.21 | 34.6 | 0 |
| Jordan Martinook | C | NYI / BUF | 80 | 8 | 6 | 14 | +2 | 20 | 1 | 1 | 13:54 | 1 | 2 | 1 | 95 | 8.4 | 18 | 79 | 0.18 | 38.8 | 0 |
| Julien Gauthier | LW | BUF | 67 | 6 | 8 | 14 | -7 | 32 | 0 | 0 | 10:06 | 0 | 1 | 0 | 70 | 8.6 | 7 | 67 | 0.21 | 45.9 | 0 |
| Oskar Sundqvist | C | BUF | 82 | 3 | 11 | 14 | -10 | 14 | 1 | 0 | 11:43 | 0 | 0 | 0 | 81 | 3.7 | 5 | 52 | 0.17 | 49.7 | 0 |
| Noah Juulsen | D | BUF | 55 | 4 | 8 | 12 | +1 | 83 | 0 | 0 | 15:54 | 0 | 0 | 0 | 36 | 11.1 | 45 | 113 | 0.22 | - | 0 |
| Zemgus Girgensons | C | BUF | 82 | 5 | 4 | 9 | -12 | 35 | 0 | 0 | 7:26 | 0 | 0 | 0 | 43 | 11.6 | 5 | 44 | 0.11 | 48.1 | 0 |
| Sam Carrick | C | BUF | 81 | 4 | 5 | 9 | -10 | 31 | 0 | 0 | 7:53 | 1 | 1 | 0 | 43 | 9.3 | 5 | 38 | 0.11 | 50.5 | 0 |
| Grant Hutton (R) | D | BUF | 18 | 0 | 4 | 4 | +4 | 10 | 0 | 0 | 13:45 | 0 | 0 | 0 | 8 | 0.0 | 10 | 19 | 0.22 | - | 0 |
| Brendan Smith | LW | BUF | 5 | 0 | 2 | 2 | +4 | 12 | 0 | 0 | 14:47 | 0 | 0 | 0 | 4 | 0.0 | 2 | 7 | 0.40 | - | 0 |
| Andreas Englund | D | BUF | 4 | 0 | 1 | 1 | 0 | 4 | 0 | 0 | 13:54 | 0 | 0 | 0 | 2 | 0.0 | 1 | 7 | 0.25 | - | 0 |
| 25 Skaters | 1770 | 292 | 537 | 829 | - | 1014 | 42 | 16 | - | 76 | 215 | 2 | 2936 | - | 916 | 1936 | 11.06 | - | 1 |