| Skater | Pos | Team | GP | G | A | P | +/- | PiM | GW | GT | ATOI | PPG | SHG | S | S% | BkS | Hits | P/GP | FO% | HT |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sidney Crosby | C | BUF | 82 | 36 | 52 | 88 | +26 | 81 | 4 | 3 | 16:32 | 10 | 0 | 264 | 13.6 | 7 | 120 | 1.07 | 52.7 | 0 |
| Marian Gaborik | RW | BUF | 82 | 32 | 54 | 86 | +24 | 28 | 3 | 3 | 15:18 | 14 | 0 | 296 | 10.8 | 8 | 54 | 1.05 | 35.5 | 2 |
| Derek Roy | C | BUF | 82 | 28 | 58 | 86 | +22 | 34 | 9 | 2 | 21:28 | 9 | 0 | 260 | 10.8 | 17 | 94 | 1.05 | 52.6 | 1 |
| Thomas Vanek | LW | BUF | 82 | 28 | 48 | 76 | +23 | 36 | 4 | 0 | 16:31 | 8 | 0 | 262 | 10.7 | 5 | 74 | 0.93 | 35.7 | 0 |
| Jason Pominville | RW | BUF | 82 | 35 | 39 | 74 | +18 | 26 | 3 | 1 | 20:08 | 12 | 0 | 229 | 15.3 | 18 | 47 | 0.90 | 33.8 | 1 |
| Chris Pronger | D | BUF | 82 | 17 | 56 | 73 | +20 | 92 | 3 | 0 | 23:34 | 9 | 0 | 152 | 11.2 | 121 | 76 | 0.89 | - | 0 |
| Drew Stafford | RW | BUF | 82 | 24 | 27 | 51 | +24 | 9 | 4 | 0 | 13:31 | 0 | 0 | 169 | 14.2 | 4 | 12 | 0.62 | 38.3 | 0 |
| Paul Gaustad | C | BUF | 82 | 16 | 33 | 49 | +25 | 217 | 1 | 0 | 13:53 | 1 | 0 | 123 | 13.0 | 8 | 196 | 0.60 | 55.1 | 1 |
| Colby Armstrong | LW | BUF | 82 | 12 | 34 | 46 | +16 | 72 | 3 | 1 | 17:49 | 4 | 0 | 127 | 9.4 | 7 | 100 | 0.56 | 33.0 | 0 |
| Antti Miettinen | LW | BUF | 82 | 17 | 18 | 35 | +35 | 12 | 4 | 1 | 12:23 | 1 | 0 | 124 | 13.7 | 10 | 20 | 0.43 | 38.8 | 0 |
| Darryl Sydor | D | BUF | 82 | 9 | 21 | 30 | +24 | 15 | 1 | 2 | 20:19 | 6 | 0 | 70 | 12.9 | 86 | 7 | 0.37 | - | 0 |
| Anton Volchenkov | D | BUF | 79 | 8 | 21 | 29 | +25 | 194 | 4 | 1 | 21:41 | 4 | 0 | 75 | 10.7 | 73 | 175 | 0.37 | - | 0 |
| Hal Gill | D | BUF | 82 | 9 | 17 | 26 | +26 | 144 | 2 | 1 | 18:13 | 3 | 0 | 59 | 15.3 | 95 | 161 | 0.32 | - | 0 |
| Brendan Witt | D | BUF | 82 | 6 | 16 | 22 | +21 | 237 | 3 | 0 | 20:46 | 2 | 0 | 62 | 9.7 | 84 | 205 | 0.27 | - | 0 |
| Henrik Tallinder | D | BUF | 82 | 5 | 16 | 21 | +20 | 48 | 1 | 1 | 14:46 | 0 | 0 | 51 | 9.8 | 53 | 49 | 0.26 | - | 0 |
| Scott Nichol | C | BUF | 76 | 3 | 6 | 9 | +4 | 29 | 0 | 0 | 9:58 | 0 | 0 | 41 | 7.3 | 13 | 38 | 0.12 | 54.1 | 0 |
| Patrick Kaleta | RW | BUF | 82 | 3 | 5 | 8 | +3 | 65 | 0 | 0 | 7:46 | 0 | 0 | 48 | 6.2 | 12 | 102 | 0.10 | 24.1 | 0 |
| Cody McLeod | LW | BUF | 82 | 4 | 2 | 6 | -4 | 88 | 0 | 0 | 6:28 | 0 | 0 | 45 | 8.9 | 2 | 77 | 0.07 | 30.2 | 0 |
| Chris Butler (R) | D | BUF | 3 | 0 | 2 | 2 | +2 | 0 | 0 | 0 | 14:20 | 0 | 0 | 1 | 0.0 | 0 | 2 | 0.67 | - | 0 |
| Darroll Powe (R) | C | BUF | 6 | 0 | 0 | 0 | -4 | 0 | 0 | 0 | 5:50 | 0 | 0 | 1 | 0.0 | 0 | 0 | 0.00 | 44.0 | 0 |
| 20 Skaters | 1476 | 292 | 525 | 817 | - | 1427 | 49 | 16 | - | 83 | 0 | 2459 | - | 623 | 1609 | 10.65 | - | 5 |